Structure of the 5′ untranslated region in SARS-CoV-2 genome and its specific recognition by innate immune system<i>via</i>the human oligoadenylate synthase 1-Reference-Cited by-同舟云学术

Structure of the 5′ untranslated region in SARS-CoV-2 genome and its specific recognition by innate immune systemviathe human oligoadenylate synthase 1

Published:2022 Issue:13 Volume:58 Page:2176-2179
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Bignon Emmanuelle¹^ORCID,Miclot Tom¹²,Terenzi Alessio²^ORCID,Barone Giampaolo²^ORCID,Monari Antonio³^ORCID

Affiliation:

1. Université de Lorraine and CNRS, LPCT UMR 7019, F-54000 Nancy, France

2. Department of Biological, Chemical and Pharmaceutical Sciences, Universitá degli Studi di Palermo, via delle Scienze 90126, Palermo, Italy

3. Université de Paris, CNRS, ITODYS, F-75006, Paris, France

Abstract

The structure of the RNA SL1 of the 5′-untranslated region of SARS-CoV-2 genome is investigated. We also highlight the specific interactions of SL1 with OAS1 triggering the innate immune response.

Funder

Centre National de la Recherche Scientifique

Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D1CC07006A

Reference26 articles.

1. A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity

2. A prenylated dsRNA sensor protects against severe COVID-19

3. SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

4. Endomembrane targeting of human OAS1 p46 augments antiviral activity

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