Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment-Reference-Cited by-同舟云学术

Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment

Published:2016 Issue:46 Volume:52 Page:7368-7371
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Agnew Lauren R.¹²³⁴⁵,Cruickshank Dyanne L.⁵⁶⁷⁸,McGlone Thomas¹⁹¹⁰¹¹⁴,Wilson Chick C.¹²³⁴⁵

Affiliation:

1. EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation

2. University of Bath

3. Bath

4. UK

5. Department of Chemistry

6. University of Cape Town

7. Rondebosch

8. South Africa

9. c/o Strathclyde Institute for Pharmacy and Biomedical Sciences

10. Technology and Innovation Centre

11. Glasgow

Abstract

A designed multi-component templating approach to paracetamol form-II provides a reproducible route to scalable (>100 g in a single run) production of this previously elusive polymorph, with its enhanced compressibility and solubility.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC01032F

Reference23 articles.

1. Baicalein–Nicotinamide Cocrystal with Enhanced Solubility, Dissolution, and Oral Bioavailability

2. Improving the Solubility of Lenalidomide via Cocrystals

3. Pharmaceutical cocrystals and poorly soluble drugs

4. Use of pharmaceutical salts and cocrystals to address the issue of poor solubility

Cited by 42 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Quality by Design Considerations for Drop-on-Demand Point-of-Care Pharmaceutical Manufacturing of Precision Medicine;Molecular Pharmaceutics;2024-04-25

2. Obtaining two polymorphic forms of paracetamol within the phase diagram with PEG 1500;European Journal of Pharmaceutics and Biopharmaceutics;2024-02

3. Revealing the mechanism of polymer inhibition of 2,4-dichlorophenoxyacetic acid Polymorphs phase transition by experimental and molecular dynamics simulation;Journal of Molecular Liquids;2024-01

4. Crystallization of Metastable Isonicotinamide Polymorphs and Prevention of Concomitant Crystallization by Additives;Crystal Growth & Design;2023-11-13

5. Pursuing Green and Efficient Agriculture from Molecular Assembly: A Review of Solid-State Forms on Agrochemicals;Journal of Agricultural and Food Chemistry;2023-07-07