G-quadruplex DNA selective targeting for anticancer therapy: a computational study of a novel Pt<sup>II</sup> monofunctional complex activated by adaptive binding-Reference-Cited by-同舟云学术

G-quadruplex DNA selective targeting for anticancer therapy: a computational study of a novel Pt^II monofunctional complex activated by adaptive binding

Published:2023 Issue:38 Volume:52 Page:13517-13527
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Belletto Daniele¹,Ponte Fortuna¹,Sanna Nico²,Scoditti Stefano¹^ORCID,Sicilia Emilia¹^ORCID

Affiliation:

1. Department of Chemistry and Chemical Technologies, Università della Calabria, 87036 Arcavacata di Rende, CS, Italy

2. Department for Innovation in Biology Agro-Food and Forest Systems (DIBAF), University of Tuscia, Largo dell'Università snc, 01100 Viterbo, Italy

Abstract

A novel monofunctional PtII complex, whose selectivity for a G-quadruplex is triggered by adaptive binding, has been computationally investigated. DFT and molecular dynamics calculations were performed in order to shed light on the mechanism of action.

Funder

Associazione Italiana per la Ricerca sul Cancro

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/DT/D3DT02678G

Reference52 articles.

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4. Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics

5. Quadruplex DNA: sequence, topology and structure

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