Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake-Reference-Cited by-同舟云学术

Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake

Published:2022 Issue:7 Volume:3 Page:895-904
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

de Araujo Aline D.¹^ORCID,Lim Junxian¹^ORCID,Wu Kai-Chen¹^ORCID,Hoang Huy N.¹^ORCID,Nguyen Huy T.¹^ORCID,Fairlie David P.¹^ORCID

Affiliation:

1. Division of Chemistry and Structural Biology, ARC Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia

Abstract

Surveying macrocycles for mimicking a helical tumor suppressor protein, resisting breakdown by proteases, and entering cancer cells.

Funder

National Health and Medical Research Council

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CB/D1CB00231G

Reference57 articles.

1. Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

2. Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

3. Drugging the 'undruggable' cancer targets

4. Principles of protein-protein interactions.

5. Consecutive Cyclic Pentapeptide Modules Form Shortα-Helices that are Very Stable to Water and Denaturants

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