Computational design and experimental characterisation of a stable human heparanase variant-Reference-Cited by-同舟云学术

Computational design and experimental characterisation of a stable human heparanase variant

Published:2022 Issue:3 Volume:3 Page:341-349
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Whitefield Cassidy¹^ORCID,Hong Nansook¹^ORCID,Mitchell Joshua A.¹^ORCID,Jackson Colin J.¹²

Affiliation:

1. Research School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia

2. Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Australian National University, Canberra, ACT 2601, Australia

Abstract

A mutant heparanase that exhibits wild type structure and activity but can be heterologously produced in bacterial protein expression systems.

Funder

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CB/D1CB00239B

Reference83 articles.

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4. Sulfated Oligosaccharides Promote Hepatocyte Growth Factor Association and Govern Its Mitogenic Activity

5. Stromal Cell-derived Factor-1α Associates with Heparan Sulfates through the First β-Strand of the Chemokine

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