Structural guidelines for stabilization of α-helical coiled coils via PEG stapling

Author:

Xiao Qiang1,Jones Zachary B.1,Hatfield Samantha C.1,Ashton Dallin S.1,Dalley Nicholas A.1,Dyer Cody D.1,Evangelista Judah L.2,Price Joshua L.1ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA

2. Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA

Abstract

Here we identify key criteria for designing PEG-stapled coiled coils with increased conformational and proteolytic stability.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

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