The rapid construction and biological evaluation of densely substituted pyrrolo[1,2-a]indoles via a BF3·OEt2-assisted cascade approach-Reference-Cited by-同舟云学术

The rapid construction and biological evaluation of densely substituted pyrrolo[1,2-a]indoles via a BF₃·OEt₂-assisted cascade approach

Published:2023 Issue:48 Volume:21 Page:9659-9668
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mali Ghanshyam¹,Kumar Yadav Vinay²,Priya Himani¹,Shukla Manjari²^ORCID,Pandey Peeyush¹,Kumar Akhilesh³,Paranjothy Manikandan¹^ORCID,Bhattacharyya Sudipta²,Erande Rohan D.¹^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Technology Jodhpur, Jodhpur 342037, Rajasthan, India

2. Department of Bioscience & Bioengineering, Indian Institute of Technology Jodhpur, Jodhpur 342037, Rajasthan, India

3. Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea

Abstract

BF3·OEt2-promoted cascade reactions revealed varied derivatives of pyrrolo[1,2-a]indoles, supported by DFT, whose biological investigation highlights anti-mycobacterial therapeutic leads.

Funder

Indian Institute of Technology Jodhpur

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01457F

Reference46 articles.

1. Cascade Reactions in Total Synthesis

2. The art of total synthesis through cascade reactions

3. Recent advances in the synthesis of indole embedded heterocycles with 3-diazoindolin-2-imines

4. Asymmetric (4+n) Cycloadditions of Indolyldimethanols for the Synthesis of Enantioenriched Indole‐Fused Rings

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