The discovery of novel antifungal scaffolds by structural simplification of the natural product sampangine-Reference-Cited by-同舟云学术

The discovery of novel antifungal scaffolds by structural simplification of the natural product sampangine

Published:2015 Issue:78 Volume:51 Page:14648-14651
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Jiang Zhigan¹²³⁴⁵,Liu Na¹²³⁴,Hu Dandan¹²³⁴,Dong Guoqiang¹²³⁴,Miao Zhenyuan¹²³⁴,Yao Jianzhong¹²³⁴,He Haiying⁵³⁴,Jiang Yuanying¹²³⁴,Zhang Wannian¹²³⁴,Wang Yan¹²³⁴,Sheng Chunquan¹²³⁴

Affiliation:

1. School of Pharmacy

2. Second Military Medical University

3. Shanghai

4. China

5. State Key Laboratory of Drug Lead Compound Research

Abstract

Structural simplification of the natural product sampangine led to the discovery of two novel antifungal compounds with excellent activity and low toxicity.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C5CC05699C

Reference41 articles.

1. Gordon M. Cragg, D.Phil., D.Sc. (h.c.): A Man for All Natural Products

2. Reactivation of Kaposi's sarcoma-associated herpesvirus by natural products from Kaposi's sarcoma endemic regions

3. Natural Products in Medicinal Chemistry

4. Tackling Human Fungal Infections

5. Evaluation of aminocandin and caspofungin against Candida glabrata including isolates with reduced caspofungin susceptibility

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