Regioselective [3 + 2]-annulation of hydrazonyl chlorides with 1,3-dicarbonyl compounds for assembling of polysubstituted pyrazoles-Reference-Cited by-同舟云学术

Regioselective [3 + 2]-annulation of hydrazonyl chlorides with 1,3-dicarbonyl compounds for assembling of polysubstituted pyrazoles

Published:2018 Issue:42 Volume:16 Page:7811-7814
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Liu Kun¹²³⁴⁵,Shang Xinye¹²³⁴⁵,Cheng Yuyu⁶⁷⁸⁵,Chang Xiaoyong⁶⁷⁸⁵,Li Pengfei⁶⁷⁸⁵,Li Wenjun¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. School of Pharmacy

3. Qingdao University

4. Qingdao

5. China

6. Department of Chemistry and Shenzhen Grubbs Institute

7. Southern University of Science and Technology

8. Shenzhen

Abstract

The facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and 1,3-dicarbonyl compounds has been developed. Hydrazonyl chlorides reacted with N-phenyl-3-oxobutanamides smoothly to afford a series of polysubstituted pyrazoles in 67–98% yields via the [3 + 2]-cycloaddition.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB02352B

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