Solution-phase synthesis of oligodeoxyribonucleotides using the H-phosphonate method with N-unprotected 5′-phosphite monomers-Reference-Cited by-同舟云学术

Solution-phase synthesis of oligodeoxyribonucleotides using the H-phosphonate method with N-unprotected 5′-phosphite monomers

Published:2021 Issue:60 Volume:11 Page:38094-38107
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Matsuda Hiromasa¹²,Yoshida Erina¹,Shinoda Takaaki¹,Sato Kazuki¹^ORCID,Hara Rintaro Iwata¹³^ORCID,Wada Takeshi¹^ORCID

Affiliation:

1. Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan

2. CMC Production Technology Laboratories, MTPC Production Technology & Supply Chain Management Division, Mitsubishi Tanabe Pharma Corporation, 3-16-89 Kashima, Yodogawa-ku, Osaka 532-8505, Japan

3. Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan

Abstract

A new strategy for a solution-phase synthesis of oligodeoxyribonucleotides with 5′-phosphite monomers synthesized in a single step from unprotected 2′-deoxyribonucleosides.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA06619F

Reference34 articles.

1. Structural DNA Nanotechnology: State of the Art and Future Perspective

2. RNA-Targeted Therapeutics

3. DNA Microarray Technology: Devices, Systems, and Applications

4. Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

5. Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach

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