Synthesis of cyclohexapeptides as antimalarial and anti-trypanosomal agents

Author:

Peña S.12345,Fagundez C.12345,Medeiros A.67589,Comini M.675,Scarone L.12345,Sellanes D.12345,Manta E.12345,Tulla-Puche J.1011121314,Albericio F.1011121314,Stewart L.151617,Yardley V.151617,Serra G.12345

Affiliation:

1. Cátedra de Química Farmacéutica

2. (DQO)

3. Facultad de Química

4. Universidad de la República

5. Montevideo, Uruguay

6. Group Redox Biology of Trypanosomes

7. Institut Pasteur de Montevideo

8. Departamento de Bioquímica

9. Facultad de Medicina

10. Institute for Research in Biomedicine (IRB Barcelona)

11. 08028-Barcelona, Spain

12. Centre on Bioengineering

13. Biomaterials and Nanomedicine

14. Barcelona Science Park

15. Faculty of Infectious & Tropical Disease

16. LSHTM

17. London, UK

Abstract

Azolic and non-azolic cyclohexapeptides were obtained and/or evaluated as promising antimalarial and/or anti-trypanosomal agents.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Reference39 articles.

1. World Malaria Report, Geneva, World Health Organization, 2012, http://www.who.int/malaria/publications/world_malaria_report_2012/en/index.html

2. World Health Organization , Research Priorities for Chagas Disease, Human African Trypanosomiasis and Leishmaniasis , Technical Report of the TDR Disease Reference Group on Chagas Disease, Human African Trypanosomiasis and Leishmaniasis, Technical Report Series no. 975, 2012 , ISBN 978 92 4 120975 5, http://www.who.int/tdr/publications/research_priorities/en/index.html

3. Neglected Tropical Diseases: Multi-Target-Directed Ligands in the Search for Novel Lead Candidates against Trypanosoma and Leishmania

4. Chemotherapy of human African trypanosomiasis: current and future prospects

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