Recognition triggered assembly of split aptamers to initiate a hybridization chain reaction for wash-free and amplified detection of exosomes

Author:

Chen Juan12345,Tang Jinlu6457,Meng Hong-Min12345ORCID,Liu Zhuo12345,Wang Lin8457,Geng Xin12345,Wu Yanan12345,Qu Lingbo12345,Li Zhaohui12345ORCID

Affiliation:

1. College of Chemistry

2. Green Catalysis Center

3. Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications

4. Zhengzhou University

5. Zhengzhou 450001

6. School of Basic Medical Sciences

7. P. R. China

8. The Academy of Medical Sciences

Abstract

A novel split aptamer-based system was developed for the amplified detection of exosomes in situ assisted by a target-induced HCR.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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