Small molecule additive enhances cell uptake of 5-aminolevulinic acid and conversion to protoporphyrin IX-Reference-Cited by-同舟云学术

Small molecule additive enhances cell uptake of 5-aminolevulinic acid and conversion to protoporphyrin IX

Published:2016 Issue:11 Volume:15 Page:1408-1416
ISSN:1474-905X
Container-title:Photochemical & Photobiological Sciences
language:en
Short-container-title:Photochem. Photobiol. Sci.

Author:

Harmatys Kara M.¹²³⁴⁵,Musso Anthony J.¹²³⁴⁵,Clear Kasey J.¹²³⁴⁵,Smith Bradley D.¹²³⁴⁵

Affiliation:

1. Department of Chemistry and Biochemistry

2. 236 Nieuwland Science Hall

3. University of Notre Dame

4. Notre Dame

5. USA

Abstract

Cells incubated with an admixture of 5-ALA (100 μM) and a zinc(ii)-bis(dipicolylamine) compound (10 μM) produced 3-fold more protoporphyrin IX than cells treated with 5-ALA alone.

Funder

National Institute of General Medical Sciences

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/PP/C6PP00151C

Reference48 articles.

1. Aminolevulinic acid (ALA): photodynamic detection and potential therapeutic applications

2. 5-Aminolevulinic acid-based photodynamic therapy

3. Photodynamic Therapy in Dermatology

4. Detection of Early Bladder Cancer by 5-Aminolevulinic Acid Induced Porphyrin Fluorescence

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