Squaryl group modified phosphoglycolipid analogs as potential modulators of GPR55

Author:

Ding Feiqing1234ORCID,Guy Adam T.534ORCID,Greimel Peter534ORCID,Hirabayashi Yoshio6234,Kamiguchi Hiroyuki534ORCID,Ito Yukishige1234ORCID

Affiliation:

1. Synthetic Cellular Chemistry Laboratory

2. RIKEN

3. Wako

4. Japan

5. RIKEN Center for Brain Science

6. Cellular Informatics Laboratory

Abstract

We report the facile synthesis of a series of LPGlc analogs, their GPR dependent biological activity and a systematic analysis of the structure–activity relationship in regards to GPR55 modulation.

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

RIKEN

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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