Discovery of 2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-one derivatives as possible antileishmanial agents

Author:

Seth Anuradha12,Ghoshal Anirban23,Dewaker Varun3ORCID,Rani Ankita12,Singh Sangh Priya23,Dutta Mukul12,Katiyar Shivani1,Singh Sandeep Kumar24,Rashid Mamunur4,Wahajuddin Muhammad24ORCID,Kar Susanta12,Srivastava Ajay Kumar23ORCID

Affiliation:

1. Molecular Microbiology and Immunology Division, CSIR-Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India

2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, Uttar Pradesh, India

3. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India

4. Pharmaceutics and Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India

Abstract

A series of uniquely functionalized 2,3,-dihydro-1H-pyyrolo[3,4-b]quinolin-1-one derivatives were synthesized in one to two steps by utilizing a post-Ugi modification strategy and were evaluated for antileishmanial efficacy against visceral leishmaniasis (VL).

Funder

Science and Engineering Research Board

Department of Biotechnology , Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Reference50 articles.

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