Discovery of 2,3-dihydro-1<i>H</i>-pyrrolo[3,4-<i>b</i>]quinolin-1-one derivatives as possible antileishmanial agents-Reference-Cited by-同舟云学术

Discovery of 2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-one derivatives as possible antileishmanial agents

Published:2022 Issue:6 Volume:13 Page:746-760
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Seth Anuradha¹²,Ghoshal Anirban²³,Dewaker Varun³^ORCID,Rani Ankita¹²,Singh Sangh Priya²³,Dutta Mukul¹²,Katiyar Shivani¹,Singh Sandeep Kumar²⁴,Rashid Mamunur⁴,Wahajuddin Muhammad²⁴^ORCID,Kar Susanta¹²,Srivastava Ajay Kumar²³^ORCID

Affiliation:

1. Molecular Microbiology and Immunology Division, CSIR-Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India

2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, Uttar Pradesh, India

3. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India

4. Pharmaceutics and Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India

Abstract

A series of uniquely functionalized 2,3,-dihydro-1H-pyyrolo[3,4-b]quinolin-1-one derivatives were synthesized in one to two steps by utilizing a post-Ugi modification strategy and were evaluated for antileishmanial efficacy against visceral leishmaniasis (VL).

Funder

Science and Engineering Research Board

Department of Biotechnology , Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D2MD00078D

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