Two is better than one: difunctional high-affinity PSMA probes based on a [CpM(CO)3] (M = Re/99mTc) scaffold-Reference-Cited by-同舟云学术

Two is better than one: difunctional high-affinity PSMA probes based on a [CpM(CO)3] (M = Re/99mTc) scaffold

Published:2019 Issue:39 Volume:48 Page:14600-14605
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Frei Angelo¹²³⁴^ORCID,Fischer Eliane¹²³⁴^ORCID,Childs Bradley Covington¹²³⁴,Holland Jason P.¹²³⁴^ORCID,Alberto Roger¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Zürich

3. CH-8057 Zürich

4. Switzerland

Abstract

Multifunctional cyclopentadiene ligands are used to prepare difunctional and monofunctional, PSMA-targeting Re(i) and ^99mTc(i) complexes. The difunctional rhenium complex is shown to bind the PSMA with an order of magnitude lower K_D.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Krebsliga Schweiz

Universität Zürich

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/DT/C9DT02506E

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