Identification of the binding roles of terminal and internal glycan epitopes using enzymatically synthesized N-glycans containing tandem epitopes

Author:

Wu Zhigang1234,Liu Yunpeng1234,Ma Cheng1234,Li Lei1234,Bai Jing5678,Byrd-Leotis Lauren91034,Lasanajak Yi111034,Guo Yuxi1234,Wen Liuqing1234,Zhu He1234,Song Jing1234,Li Yanhong1213144,Steinhauer David A.91034,Smith David F.111034,Zhao Baohua5678,Chen Xi1213144,Guan Wanyi12345,Wang Peng George1234

Affiliation:

1. Department of Chemistry and Center of Diagnostics & Therapeutics

2. Georgia State University

3. Atlanta

4. USA

5. College of Life Science

6. Hebei Normal University

7. Shijiazhuang

8. China

9. Departments of Microbiology and Immunology

10. Emory University School of Medicine

11. Department of Biochemistry and Emory Comprehensive Glycomics Core

12. Department of Chemistry

13. University of California

14. Davis

Abstract

Roles of internal epitopes and modification of terminal epitopes in the glycan-binding events have been studied.

Funder

U.S. Department of Health and Human Services

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference64 articles.

1. Evolutionary Forces Shaping the Golgi Glycosylation Machinery: Why Cell Surface Glycans Are Universal to Living Cells

2. A. Varki and J. B.Lowe, in Essentials of Glycobiology, ed. A. Varki, R. D. Cummings, J. D. Esko, H. H. Freeze, P. Stanley, C. R. Bertozzi, G. W. Hart and M. E. Etzler, Cold Spring Harbor, New York, 2nd edn, 2009, ch. 6

3. Siglecs and their roles in the immune system

4. Glycan-based high-affinity ligands for toxins and pathogen receptors

5. Neurological Aspects of Human Glycosylation Disorders

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