I2-Mediated transition-metal-free aromatic C–H amination for the synthesis of benzimidazol-2-ones and related heterocycles-Reference-Cited by-同舟云学术

I2-Mediated transition-metal-free aromatic C–H amination for the synthesis of benzimidazol-2-ones and related heterocycles

Published:2018 Issue:16 Volume:42 Page:13790-13796
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Meng Yinggao¹²³⁴,Wang Bingnan¹²³⁴,Ren Linning¹²³⁴,Zhao Qiongli⁵⁴⁶²³,Yu Wenquan¹²³⁴^ORCID,Chang Junbiao¹²³⁴⁵

Affiliation:

1. College of Chemistry and Molecular Engineering

2. Zhengzhou University

3. Zhengzhou

4. China

5. Collaborative Innovation Centre of New Drug Research and Safety Evaluation

6. School of Pharmaceutical Sciences

Abstract

A practical I₂-mediated aromatic C–H amination reaction was established for benzimidazol-2-one synthesis under transition-metal-free conditions. The present reaction can be performed directly from disubstituted amines and isocyanates without the purification of the urea intermediates in a scalable fashion.

Funder

National Natural Science Foundation of China

Zhengzhou University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NJ/C8NJ03166E

Reference48 articles.

1. Searching for novel N 1 -substituted benzimidazol-2-ones as non-nucleoside HIV-1 RT inhibitors

2. Lead identification of benzimidazolone and azabenzimidazolone arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists