I2-Mediated transition-metal-free aromatic C–H amination for the synthesis of benzimidazol-2-ones and related heterocycles
Author:
Affiliation:
1. College of Chemistry and Molecular Engineering
2. Zhengzhou University
3. Zhengzhou
4. China
5. Collaborative Innovation Centre of New Drug Research and Safety Evaluation
6. School of Pharmaceutical Sciences
Abstract
A practical I2-mediated aromatic C–H amination reaction was established for benzimidazol-2-one synthesis under transition-metal-free conditions. The present reaction can be performed directly from disubstituted amines and isocyanates without the purification of the urea intermediates in a scalable fashion.
Funder
National Natural Science Foundation of China
Zhengzhou University
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,General Chemistry,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2018/NJ/C8NJ03166E
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