β-Enaminonitrile in the synthesis of tetrahydrobenzo[<i>b</i>]thiophene candidates with DFT simulation, <i>in vitro</i> antiproliferative assessment, molecular docking, and modeling pharmacokinetics-Reference-Cited by-同舟云学术

β-Enaminonitrile in the synthesis of tetrahydrobenzo[b]thiophene candidates with DFT simulation, in vitro antiproliferative assessment, molecular docking, and modeling pharmacokinetics

Published:2024 Issue:26 Volume:14 Page:18417-18430
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Elgubbi Amna S.¹^ORCID,El-Helw Eman A. E.²^ORCID,Abousiksaka Motaleb S.¹,Alzahrani Abdullah Y. A.³,Ramadan Sayed K.²^ORCID

Affiliation:

1. Chemistry Department, Faculty of Science, Misurata University, 2478, Misurata, Libya

2. Chemistry Department, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt

3. Chemistry Department, Faculty of Science and Arts, King Khalid University, Abha, Mohail Assir, Saudi Arabia

Abstract

Tetrahydrobenzo[b]thiophenes were prepared and supported with in silico analyses. In vitro antiproliferative results displayed the highest potency of imide 5, Schiff base 11, and phthalimido 12 candidates against MCF7 and HePG2 cancer cell lines.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA03363A

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