Gut relief formula attenuates dextran sulfate sodium-induced colitis by regulating NF-κB signaling and the intestinal microbiota in mice

Author:

Si Xuemeng1,Liu Ning12,Jia Hai1,Wang Jiaqi3,Pan Lina3,Dong Ling3,Rong Zhixing3,Yang Ying1,Wu Zhenlong12ORCID

Affiliation:

1. State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing 100193, China

2. Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing, 100193, China

3. Ausnutria Institute of Food and Nutrition, Ausnutria Dairy (China) Co. Ltd, Changsha 410200, Hunan, China

Abstract

Gut relief formula administration alleviated mucosal inflammation and mucosal barrier dysfunction by inhibiting STAT3 and NF-κB activity and upregulating abundances of Lactobacillus in DSS-induced colitis.

Funder

National Natural Science Foundation of China

Science and Technology Program of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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