Microflow-based dynamic combinatorial chemistry: a microscale synthesis and screening platform for the rapid and accurate identification of bioactive molecules-Reference-Cited by-同舟云学术

Microflow-based dynamic combinatorial chemistry: a microscale synthesis and screening platform for the rapid and accurate identification of bioactive molecules

Published:2019 Issue:4 Volume:4 Page:658-662
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Qiu Chuanhong¹²³⁴,Fang Zheng⁵²³⁴,Zhao Lihuan⁵²³⁴,He Wei⁵²³⁴,Yang Zhao⁶⁷⁸⁴,Liu Chengkou⁵²³⁴,Guo Kai⁵²³⁴⁹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences

2. Nanjing Tech University

3. Nanjing 211816

4. PR China

5. College of Biotechnology and Pharmaceutical Engineering

6. College of Engineering

7. China Pharmaceutical University

8. Nanjing 210009

9. State Key Laboratory of Materials-Oriented Chemical Engineering

Abstract

The first flow-based synthesis and screening platform that integrates both microflow chemistry and protein-directed dynamic combinatorial chemistry into a single modular unit was disclosed and validated by a case study.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RE/C8RE00327K

Reference45 articles.

1. Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery

2. New assay technologies for high-throughput screening

3. Signalling the fat controller