An integrated five-step continuous flow synthesis of 2-(1-cyclohexenyl)ethylamine: a key intermediate for morphinans-Reference-Cited by-同舟云学术

An integrated five-step continuous flow synthesis of 2-(1-cyclohexenyl)ethylamine: a key intermediate for morphinans

Published:2023 Issue:8 Volume:8 Page:1882-1887
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Li Zhining¹,Huang Shiqi¹,Tao Yuan¹,Jiang Meifen¹,Cheng Dang¹^ORCID,Wan Li¹,Chen Fener¹²^ORCID

Affiliation:

1. Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, P. R. China

2. Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China

Abstract

A continuous flow synthesis of 2-(1-cyclohexenyl)ethylamine started from cyclohexanone was developed through telescoping Grignard reaction and chlorination, telescoping amination and double bond rearrangement, and hydrazinolysis.

Funder

National Natural Science Foundation of China

Fudan University

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RE/D3RE00082F

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