The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer-Reference-Cited by-同舟云学术

The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer

Published:2020 Issue:81 Volume:56 Page:12238-12241
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Scattolin Thomas¹²³⁴,Bortolamiol Enrica⁵⁶⁷⁸,Palazzolo Stefano⁹¹⁰¹¹⁸,Caligiuri Isabella⁹¹⁰¹¹⁸,Perin Tiziana⁹¹⁰¹¹⁸,Canzonieri Vincenzo⁹¹⁰¹¹⁸¹²^ORCID,Demitri Nicola¹³¹⁴⁸^ORCID,Rizzolio Flavio⁵⁶⁷⁸⁹,Cavallo Luigi¹⁵¹⁶¹⁷¹⁸^ORCID,Dereli Busra¹⁵¹⁶¹⁷¹⁸,Mane Manoj V.¹⁵¹⁶¹⁷¹⁸,Nolan Steven P.¹²³⁴^ORCID,Visentin Fabiano⁵⁶⁷⁸^ORCID

Affiliation:

1. Department of Chemistry and Center for Sustainable Chemistry

2. Ghent University

3. Ghent

4. Belgium

5. Dipartimento di Scienze Molecolari e Nanosistemi

6. Università Ca’ Foscari

7. Venezia-Mestre 30174

8. Italy

9. Pathology Unit

10. Centro di Riferimento Oncologico di Aviano (CRO) IRCCS

11. Aviano 33081

12. Department of Medical, Surgical and Health Sciences

13. Elettra – Sincrotrone Trieste

14. Basovizza 34149

15. KAUST Catalysis Centre, KCC

16. King Abdullah University of Science and Technology

17. Thuwal 23955-6900

18. Saudi Arabia

Abstract

The synthesis of a new dinuclear Pd(i) complex bearing two bis(NHC) ligands is discussed. This compound exhibited excellent bioactivity against several cancer cell lines and low toxicity toward normal cells. Its mode of action is also discussed.

Funder

Associazione Italiana per la Ricerca sul Cancro

Universiteit Gent

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC03883K

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5. Design of a Versatile and Improved Precatalyst Scaffold for Palladium-Catalyzed Cross-Coupling: (η3-1-tBu-indenyl)2(μ-Cl)2Pd2

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