Non-clinical development of ozanezumab: a humanised antibody targeting the amino terminus of neurite outgrowth inhibitor A (Nogo-A)

Author:

Lynch Anthony M.123,Cleveland Matthew423,Prinjha Rabinder523,Kumar Umesh523,Stubbs Robert623,Wuerthner Jens723

Affiliation:

1. Safety Assessment

2. GlaxoSmithKline

3. UK

4. R&D Biopharm

5. Epinova DPU

6. DMPK

7. Biopharm R&D TPDM Novartis

Abstract

Ozanezumab (GSK1223249) is a humanised, Fc-disabled, monoclonal antibody (mAb) which targets the amino terminus of Neurite Outgrowth Inhibitor A (Nogo-A) which is currently being developed for the treatment of amyotrophic lateral sclerosis (ALS).

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Reference49 articles.

1. Targeting the Nogo Receptor to Treat Central Nervous System Injuries

2. Systemic Deletion of the Myelin-Associated Outgrowth Inhibitor Nogo-A Improves Regenerative and Plastic Responses after Spinal Cord Injury

3. Nogo and axon regeneration

4. Targeting the Nogo-A Signalling Pathway to Promote Recovery Following Acute CNS Injury

5. V. Meininger , P. F.Pradat, A.Crose, S.Al-Sarraj, B. R.Brooks, J. B.Caress, M.Cudkowicz, S. J.Kolb, D.Lange, P. N.Leigh, T.Meyer, S.Milleri, K. E.Morrison, R. W.Orrel, G.Peters, J. D.Rothstein, J.Shefner, A.Lavrov, N.Williams, P.Overend, J.Price, S.Bates, J.Bullman, D.Krull, A.Berges, B.Abila, G.Meno-Tetang and J.Wurthner, Safety, pharmacokinetic, and functional effects of the Nogo-A monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-man study, submitted for publication

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