Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: activation pathway to amino acid adducts-Reference-Cited by-同舟云学术

Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: activation pathway to amino acid adducts

Published:2015 Issue:6 Volume:4 Page:1565-1577
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Harjivan Shrika G.¹²³⁴⁵,Pinheiro Pedro F.¹²³⁴⁵,Martins Inês L.¹²³⁴⁵,Godinho Ana L.¹²³⁴⁵,Wanke Riccardo¹²³⁴⁵,Santos Pedro P.¹²³⁴⁵,Pereira Sofia A.⁶⁷⁸⁹⁵,Beland Frederick A.¹⁰¹¹¹²¹³,Marques M. Matilde¹²³⁴⁵,Antunes Alexandra M. M.¹²³⁴⁵

Affiliation:

1. Centro de Química Estrutural

2. Instituto Superior Técnico

3. Universidade de Lisboa

4. 1049-001 Lisboa

5. Portugal

6. Centro de Estudos de Doenças Crónicas (CEDOC)

7. NOVA Medical School

8. Universidade NOVA

9. 1169-056 Lisboa

10. Division of Biochemical Toxicology

11. National Center for Toxicological Research

12. Jefferson

13. USA

Abstract

Quinoid electrophiles from the nevirapine metabolites, 2-OH- and 3-OH-nevirapine, react with nitrogen-based bionucleophiles yielding covalent adducts.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/TX/C5TX00176E

Reference63 articles.

1. Cost effectiveness of single-dose nevirapine regimen for mothers and babies to decrease vertical HIV-1 transmission in sub-Saharan Africa

2. Single-Dose Perinatal Nevirapine plus Standard Zidovudine to Prevent Mother-to-Child Transmission of HIV-1 in Thailand

3. Response to Antiretroviral Therapy after a Single, Peripartum Dose of Nevirapine

4. Panel on Antiretroviral Therapy and Medical Management of HIV-Infected Children. Guidelines for the use of antiretroviral agents in pediatric HIV infection, Available at http://aidsinfo.nih.gov/ContentFiles/PediatricGuidelines.pdf

5. Antiretroviral Treatment Simplification With Nevirapine in Protease Inhibitor–Experienced Patients With HIV-Associated Lipodystrophy

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Electroanalytical sensors for antiretroviral drugs determination in pharmaceutical and biological samples: A review;Journal of Electroanalytical Chemistry;2022-09

2. Amino Acid and Biogenic Amine Adductions Derived from Reactive Metabolites;Current Drug Metabolism;2021-12

3. Synthesis and evaluation of nevirapine analogs to study the metabolic activation of nevirapine;Drug Metabolism and Pharmacokinetics;2020-04

4. Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death;Journal of Medicinal Chemistry;2020-02-17

5. Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity;Drug Metabolism Reviews;2019-01-02