An investigation of nitrile transforming enzymes in the chemo-enzymatic synthesis of the taxol sidechain-Reference-Cited by-同舟云学术

An investigation of nitrile transforming enzymes in the chemo-enzymatic synthesis of the taxol sidechain

Published:2015 Issue:28 Volume:13 Page:7803-7812
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wilding Birgit¹²³⁴⁵,Veselá Alicja B.⁶⁷⁸,Perry Justin J. B.⁹¹⁰¹¹¹²¹³,Black Gary W.⁹¹⁰¹¹¹²¹³,Zhang Meng⁹¹⁰¹¹¹²¹³,Martínková Ludmila⁶⁷⁸,Klempier Norbert¹²³⁴⁵

Affiliation:

1. acib GmbH (Austrian Centre of Industrial Biotechnology)

2. c/o Institute of Organic Chemistry

3. Graz University of Technology

4. A-8010 Graz

5. Austria

6. Institute of Microbiology of the Academy of Sciences of the Czech Republic

7. CZ-14220 Prague

8. Czech Republic

9. Industrial Biotechnology Research Group

10. Department of Applied Sciences

11. Faculty of Health and Life Sciences

12. Northumbria University

13. Newcastle upon Tyne NE1 8ST

Abstract

Nitrile transforming enzymes, namely nitrilases and nitrile hydratases, are investigated for the enzymatic hydrolysis of two taxol sidechain precursors, an openchain α-hydroxy-β-amino nitrile and a cyanodihydrooxazole.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01191D

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