Selective FRET nano probe based on carbon dots and naphthalimide–isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury

Author:

Wu Yueci1ORCID,Sun Lu-Lu23ORCID,Han Hai-Hao23ORCID,He Xiao-Peng45ORCID,Cao Weiguo6ORCID,James Tony D.17ORCID

Affiliation:

1. Department of Chemistry, University of Bath, Bath, BA2 7AY, UK

2. Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, P. R. China

3. Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China

4. Key Laboratory for Advanced Materials, Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd, Shanghai 200237, P. R. China

5. The International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, P. R. China

6. Department of Chemistry, Shanghai University, Shanghai 200444, P. R. China

7. School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, P. R. China

Abstract

Ratiometric FRET-based probe CD–N-I was developed to detect exogenous ONOO in live cells and endogenous ONOO in APAP-induced liver injury of HepG2 cells.

Funder

China Scholarship Council

University of Bath

Shanghai University

Henan Normal University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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