Design of dual inhibitors of ROCK-I and NOX2 as potential leads for the treatment of neuroinflammation associated with various neurological diseases including autism spectrum disorder-Reference-Cited by-同舟云学术

Design of dual inhibitors of ROCK-I and NOX2 as potential leads for the treatment of neuroinflammation associated with various neurological diseases including autism spectrum disorder

Published:2015 Issue:2 Volume:11 Page:607-617
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Alokam Reshma¹²³⁴⁵,Singhal Sarthak¹²³⁴⁵,Srivathsav Geetha Sai¹²³⁴⁵,Garigipati Sowmya¹²³⁴⁵,Puppala Sripriya¹²³⁴⁵,Sriram Dharmarajan¹²³⁴⁵,Perumal Yogeeswari¹²³⁴⁵

Affiliation:

1. Computer-Aided Drug Design Lab

2. Department of Pharmacy

3. Birla Institute of Technology & Science–Pilani

4. Hyderabad–500078

5. India

Abstract

Inhibition of both ROCK-I and NOX2 to treat neuroinflammation could be very effective in the treatment of progressive neurological disorders like AD, ASD and FXS.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C4MB00570H

Reference42 articles.

1. Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

2. Animal models of Alzheimer's disease and frontotemporal dementia

3. Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism

4. Inflammation markers in relation to cognition in a healthy aging population

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