Lessons learned in engineering interrupted adenylation domains when attempting to create trifunctional enzymes from three independent monofunctional ones-Reference-Cited by-同舟云学术

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Lessons learned in engineering interrupted adenylation domains when attempting to create trifunctional enzymes from three independent monofunctional ones

Published:2020 Issue:56 Volume:10 Page:34299-34307
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lundy Taylor A.¹²³⁴⁵,Mori Shogo¹²³⁴⁵^ORCID,Garneau-Tsodikova Sylvie¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences

2. University of Kentucky

3. College of Pharmacy

4. Lexington

5. USA

Abstract

Interrupted adenylation (A) domains are fascinating examples of multifunctional enzymes with high potential for engineering. Here, limits were established in engineering trifunctional interrupted A domains.

Funder

National Science Foundation

American Foundation for Pharmaceutical Education

University of Kentucky

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA05490A

Reference35 articles.

1. Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

2. Biosynthesis of Nonribosomal Peptides

3. A new enzyme superfamily — the phosphopantetheinyl transferases

4. Engineering the Substrate Specificity of the DhbE Adenylation Domain by Yeast Cell Surface Display

5. Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity

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1. Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases;Marine Drugs;2024-07-29

2. Structural insights into the diverse prenylating capabilities of DMATS prenyltransferases;Natural Product Reports;2024

3. Protein engineering for natural product biosynthesis and synthetic biology applications;Protein Engineering, Design and Selection;2021

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