Novel O-methyl goniofufurone and 7-epi-goniofufurone derivatives: synthesis, in vitro cytotoxicity and SAR analysis-Reference-Cited by-同舟云学术

Novel O-methyl goniofufurone and 7-epi-goniofufurone derivatives: synthesis, in vitro cytotoxicity and SAR analysis

Published:2018 Issue:12 Volume:9 Page:2017-2027
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Francuz Jovana¹²³⁴⁵,Popsavin Mirjana¹²³⁴⁵,Djokić Sanja¹²³⁴⁵,Kojić Vesna⁶⁷⁴⁸⁹,Srdić-Rajić Tatjana¹⁰¹¹⁹,Rodić Marko V.¹²³⁴⁵^ORCID,Jakimov Dimitar⁶⁷⁴⁸⁹,Popsavin Velimir¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Biochemistry and Environmental Protection

3. Faculty of Sciences

4. University of Novi Sad

5. 21000 Novi Sad

6. Oncology Institute of Vojvodina

7. Faculty of Medicine

8. 21204 Sremska Kamenica

9. Serbia

10. Institute for Oncology and Radiology of Serbia

11. 11000 Belgrade

Abstract

Novel goniofufurone (1) and 7-epi-goniofufurone (2) derivatives bearing a methoxy group at the C-5 and/or C-7 positions were prepared and their in vitro antitumour activity against some human tumour cell lines was evaluated.

Funder

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00431E

Reference21 articles.

1. GoniothalamusSpecies: A Source of Drugs for the Treatment of Cancers and Bacterial Infections?

2. Styryl Lactones and Their Derivatives: Biological Activities, Mechanisms of Action and Potential Leads for Drug Design

3. Styryl-lactones from Goniothalamus species— A review

4. Synthesis and Application of [3.3.0]Furofuranone in Total Synthesis

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