Binary scaffold facilitates in situ regeneration of axons and neurons for complete spinal cord injury repair-Reference-Cited by-同舟云学术

Binary scaffold facilitates in situ regeneration of axons and neurons for complete spinal cord injury repair

Published:2021 Issue:8 Volume:9 Page:2955-2971
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Liu Dingyang¹²³⁴,Shu Muya⁵⁶⁷⁸⁴,Liu Weiyuan⁵⁶⁷⁸⁴,Shen Yeyu⁹¹⁰¹¹⁴¹²,Long Ge¹³¹⁴³⁴,Zhao Yannan⁵⁶⁷⁸⁴,Hou Xianglin⁵⁶⁷⁸⁴,Xiao Zhifeng⁵⁶⁷⁸⁴,Dai Jianwu⁵⁶⁷⁸⁴^ORCID,Li Xing¹²³⁴⁹^ORCID

Affiliation:

1. Department of Neurosurgery

2. Xiangya Hospital of Central South University

3. Changsha

4. China

5. State Key Laboratory of Molecular Developmental Biology

6. Institute of Genetics and Developmental Biology

7. Chinese Academy of Sciences

8. Beijing 100101

9. Key Laboratory of Organ Injury

10. Aging and Regenerative Medicine of Hunan Province

11. Changsha 410008

12. Department of Spine Surgery

13. Department of Anesthesia

14. the Third Xiangya Hospital of Central South University

Abstract

A binary-drug modified scaffold is able to promote both axonal and neuronal regeneration in complete spinal cord injury model. Moreover, it also facilitates synaptic formation of the regenerated neurons and axons for motor function improvement.

Funder

National Natural Science Foundation of China

Xiangya Hospital, Central South University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D0BM02212H

Reference54 articles.

1. Bridging the gap with functional collagen scaffolds: tuning endogenous neural stem cells for severe spinal cord injury repair

2. Scaffold-facilitated locomotor improvement post complete spinal cord injury: Motor axon regeneration versus endogenous neuronal relay formation