Cobalt(ii) terpyridine complexes: synthesis, characterization, antiproliferative activity and molecular docking with proteins and DNA

Author:

Chen Min1,Sun Dameng1,Li Jiahe1,Wang Zhiyuan1,Liu Hongming1ORCID,Pan Lixia2,Chen Hailan34ORCID,Ma Zhen1ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, Guangxi University, 530004 Nanning, Guangxi, P. R. China

2. National Engineering Research Center for Non-Food Biorefinery, State Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Academy of Sciences, Nanning 530007, Guangxi, P. R. China

3. School of Animal Science and Technology, Guangxi University, 530004, Nanning, Guangxi, P. R. China

4. Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, Guangxi, P. R. China

Abstract

Nine Co(ii)-terpyridine complexes were synthesized and their anticancer activity was investigated. Their interaction with DNA has been experimentally and computationally studied.

Funder

National Natural Science Foundation of China

Guangxi University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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