Dynamic kinetic resolution of transient hemiketals: a strategy for the desymmetrisation of prochiral oxetanols-Reference-Cited by-同舟云学术

Dynamic kinetic resolution of transient hemiketals: a strategy for the desymmetrisation of prochiral oxetanols

Published:2022 Issue:21 Volume:13 Page:6297-6302
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sandvoß Alexander¹²^ORCID,Maag Henning²,Daniliuc Constantin G.¹^ORCID,Schollmeyer Dieter²,Wahl Johannes M.²^ORCID

Affiliation:

1. Organisch-Chemisches Institut, Westfälische Wilhelms-Universität, Corrensstraße 36, 48149 Münster, Germany

2. Department Chemie, Johannes Gutenberg-Universität, Duesbergweg 10-14, 55128 Mainz, Germany

Abstract

Desymmetrization of prochiral oxetanols via an electron-deficient hemiketal intermediate is achieved. Key to this process is the catalyst's chiral recognition of one of the two hemiketal enantiomers enabling an efficient dynamic kinetic resolution.

Funder

Verband der Chemischen Industrie

Studienstiftung des Deutschen Volkes

Westfälische Wilhelms-Universität Münster

Johannes Gutenberg-Universität Mainz

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC01547A

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