The many faces and important roles of protein–protein interactions during non-ribosomal peptide synthesis-Reference-Cited by-同舟云学术

The many faces and important roles of protein–protein interactions during non-ribosomal peptide synthesis

Published:2018 Issue:11 Volume:35 Page:1120-1139
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Izoré Thierry¹²³⁴⁵^ORCID,Cryle Max J.¹²³⁴⁵^ORCID

Affiliation:

1. The Monash Biomedicine Discovery Institute

2. Department of Biochemistry and Molecular Biology and ARC Centre of Excellence in Advanced Molecular Imaging

3. Monash University

4. Clayton

5. Australia

Abstract

Non-ribosomal peptide synthetase (NRPS) machineries are complex, multi-domain proteins that are responsible for the biosynthesis of many important, peptide-derived compounds. In this review, we present the current state of understanding of the protein–protein interactions that govern NRPS-mediated biosynthesis.

Funder

National Health and Medical Research Council

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NP/C8NP00038G

Reference129 articles.

1. Nonribosomal Peptide Synthesis-Principles and Prospects

2. Nonproteinogenic Amino Acid Building Blocks for Nonribosomal Peptide and Hybrid Polyketide Scaffolds