Novel fungal diphenyl ether biosynthetic gene clusters encode a promiscuous oxidase for elevated antibacterial activities-Reference-Cited by-同舟云学术

Novel fungal diphenyl ether biosynthetic gene clusters encode a promiscuous oxidase for elevated antibacterial activities

Published:2024 Issue:35 Volume:15 Page:14248-14253
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Qingpei¹^ORCID,Gao Shuaibiao¹^ORCID,Fang Jin¹^ORCID,Gong Yifu¹,Zheng Yiling¹^ORCID,Xu Yao¹,Zhang Dan¹^ORCID,Wei Jiayuan¹,Liao Liangxiu¹,Yao Ming¹,Wang Wenjing¹,Han Xiaole²^ORCID,Chen Fusheng³⁴^ORCID,Molnár István⁵^ORCID,Yang Xiaolong¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, P.R. China

2. School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, P.R. China

3. School of Life Sciences, Guizhou Normal University, Guiyang 550025, P.R. China

4. College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, P.R. China

5. VTT Technical Research Centre of Finland, FI-02044 VTT, Espoo, Finland

Abstract

This work describes a novel pathway for fungal diphenyl ether (DPE) biosynthesis, including a promiscuous hydroxylase whose substrate range is modulated by its C-terminus. DPEs may provide antibiotics against multidrug-resistant human pathogens.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

South-Central University for Nationalities

Teknologian Tutkimuskeskus VTT

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC01435A

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