A silicon-containing aryl/penta-1,4-dien-3-one/amine hybrid exhibits antiproliferative effects on breast cancer cells by targeting the HSP90 C-terminus without inducing heat-shock response-Reference-Cited by-同舟云学术

A silicon-containing aryl/penta-1,4-dien-3-one/amine hybrid exhibits antiproliferative effects on breast cancer cells by targeting the HSP90 C-terminus without inducing heat-shock response

Published:2023 Issue:12 Volume:14 Page:2625-2639
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Liao Yu-Ting¹,Du Xin-Ye¹²,Wang Mei¹,Zheng Chun-Xia¹,Li Dashan¹,Chen Chuan-Huizi¹,Li Rong-Tao²,Shao Li-Dong¹^ORCID

Affiliation:

1. Yunnan Key Laboratory of Southern Medicinal Resources, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China

2. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China

Abstract

Compound 1z, a thermostable silicon-containing aryl/penta-1,4-dien-3-one/amine hybrid kills breast cancer cells by targeting the HSP90 C-terminus without inducing heat-shock response.

Funder

National Natural Science Foundation of China

Ten Thousand Talent Plans for Young Top-notch Talents of Yunnan Province

Yunnan Provincial Department of Education

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00431G

Reference53 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries