Direct C-4 alkylation of quinazoline N-oxides with ethers via an oxidative cross-coupling reaction under metal-free conditions-Reference-Cited by-同舟云学术

Direct C-4 alkylation of quinazoline N-oxides with ethers via an oxidative cross-coupling reaction under metal-free conditions

Published:2018 Issue:45 Volume:16 Page:8724-8731
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yang Qin¹²³⁴⁵,Lou Minhao¹²³⁴⁵,Yin Zhijian¹²³⁴⁵,Deng Zhihong¹²³⁴⁵,Ding Qiuping¹²³⁴⁵^ORCID,Peng Yiyuan¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Functional Small Organic Molecule

2. Ministry of Education

3. and Jiangxi Province's Key Laboratory of Green Chemistry

4. Jiangxi Normal University

5. Nanchang

Abstract

A novel and efficient protocol for the direct C-4 alkylation of quinazoline-3-oxides via radical oxidative coupling between quinazoline 3-oxides and ethers in the presence of TBHP is presented.

Funder

National Natural Science Foundation of China

Jiangxi Provincial Department of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01429A

Reference72 articles.

1. Synthesis of quinazolinones and quinazolines

2. Quinoline, quinazoline and acridone alkaloids

3. The chemistry of recently isolated naturally occurring quinazolinone alkaloids

4. Erlotinib: a new therapeutic approach for non-small cell lung cancer

5. Gefitinib — a novel targeted approach to treating cancer

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