Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming-Reference-Cited by-同舟云学术

Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming

Published:2017 Issue:2 Volume:8 Page:1116-1126
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Roberts Douglas M.¹²³⁴⁵,Bartel Christoph⁵⁶⁷⁸⁹,Scott Alan¹²³⁴,Ivison David¹²³⁴,Simpson Thomas J.¹²³⁴,Cox Russell J.¹²³⁴⁵^ORCID

Affiliation:

1. School of Chemistry

2. University of Bristol

3. Bristol BS8 1TS

4. UK

5. Institute for Organic Chemistry

6. BMWZ

7. Leibniz Universität Hannover

8. Hannover

9. Germany

Abstract

The complete stereochemical course and substrate selectivity of the enoyl reductase domain from the fungal polyketide synthase squalestatin tetraketide synthase (SQTKS) have been determined.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

University of Bristol

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC03496A

Reference35 articles.