Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos-Reference-Cited by-同舟云学术

Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos

Published:2016 Issue:2 Volume:5 Page:609-620
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Hu Hejing¹²³⁴⁵,Li Qiuling¹²³⁴⁵,Jiang Lizhen¹²³⁴⁵,Zou Yang¹²³⁴⁵,Duan Junchao¹²³⁴⁵,Sun Zhiwei¹²³⁴⁵

Affiliation:

1. Department of Toxicology and Sanitary Chemistry

2. School of Public Health

3. Capital Medical University

4. Beijing 100069

5. P.R. China

Abstract

Silica nanoparticle-induced toxicity in zebrafish embryos affected expression of 2515 genes. Pathway analysis and Signal-net analysis indicated that the gap junction, vascular smooth muscle contraction, and metabolic pathways, apoptosis, the MAPK signaling pathway, the calcium signaling pathway and the JAK-STAT signaling pathway were the most prominent significant pathways in SiNP-induced toxicity in zebrafish embryos.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2016/TX/C5TX00383K

Reference50 articles.

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