Stability and bioactivity of thrombin binding aptamers modified with d-/l-isothymidine in the loop regions
Author:
Affiliation:
1. State Key Laboratory of Natural and Biomimetic Drugs
2. School of Pharmaceutical Sciences
3. Peking University
4. Beijing 100191, PR China
Abstract
d-/l-IsoT were used to modify the loop regions of TBA and greatly improved its bioactivity as well as stability.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB01525H
Reference52 articles.
1. In vivo veritas: Using yeast to probe the biological functions of G-quadruplexes
2. Quadruplex DNA: sequence, topology and structure
3. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
4. Prevalence of quadruplexes in the human genome
5. G-Quadruplex Formation by Human Telomeric Repeats-Containing RNA in Na+ Solution
Cited by 44 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. High-content tailoring strategy to improve the multifunctionality of functional nucleic acids;Biosensors and Bioelectronics;2024-10
2. Unlocking precision in aptamer engineering: a case study of the thrombin binding aptamer illustrates why modification size, quantity, and position matter;Nucleic Acids Research;2024-09-01
3. Emerging Progress of RNA-Based Antitumor Therapeutics;International Journal of Biological Sciences;2023
4. PROGRESS OF OLIGONUCLEOTIDE THERAPEUTICS TARGET TO RNA;Nucleic Acids in Medicinal Chemistry and Chemical Biology;2022-12-16
5. Recent advances in aptamer-based targeted drug delivery systems for cancer therapy;Frontiers in Bioengineering and Biotechnology;2022-08-16
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3