Light-driven photoswitching of quinazoline analogues of combretastatin A-4 as an effective approach for targeting skin cancer cells-Reference-Cited by-同舟云学术

Light-driven photoswitching of quinazoline analogues of combretastatin A-4 as an effective approach for targeting skin cancer cells

Published:2021 Issue:35 Volume:19 Page:7670-7677
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Scherbakov A. M.¹,Balakhonov R. Yu.²^ORCID,Salnikova D. I.¹³,Sorokin D. V.¹,Yadykov A. V.²,Markosyan A. I.⁴,Shirinian V. Z.²^ORCID

Affiliation:

1. Department of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, Kashirskoye sh. 24, Moscow 115522, Russian Federation

2. N. D. Zelinsky Institute of Organic Chemistry, RAS, Moscow, Russian Federation

3. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russian Federation

4. Scientific Technological Center of Organic and Pharmaceutical Chemistry, NAS RA, Yerevan, Armenia

Abstract

A study of the photochemical properties and antiproliferative activity of new quinazoline analogues of combretastatin A-4 found that irradiation with UV or sunlight leads to a significant increase in activity towards epidermoid carcinoma cells.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01362A

Reference79 articles.

1. Recent advances in combretastatin based derivatives and prodrugs as antimitotic agents

2. Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth

3. Development of combretastatins as potent tubulin polymerization inhibitors

4. The Use of Stilbene Scaffold in Medicinal Chemistry and Multi- Target Drug Design

5. Developments of isoCombretastatin A-4 derivatives as highly cytotoxic agents

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