An integrated molecular dynamics, principal component analysis and residue interaction network approach reveals the impact of M184V mutation on HIV reverse transcriptase resistance to lamivudine-Reference-Cited by-同舟云学术

An integrated molecular dynamics, principal component analysis and residue interaction network approach reveals the impact of M184V mutation on HIV reverse transcriptase resistance to lamivudine

Published:2014 Issue:8 Volume:10 Page:2215-2228
ISSN:1742-206X
Container-title:Mol. BioSyst.
language:en
Short-container-title:Mol. BioSyst.

Author:

Bhakat Soumendranath¹²³,Martin Alberto J. M.⁴⁵⁶⁷⁸,Soliman Mahmoud E. S.¹²³

Affiliation:

1. School of Health Sciences

2. University of KwaZulu-Natal

3. Durban 4001, South Africa

4. Computational Biology Lab

5. Fundación Ciencia & Vida

6. Santiago, Chile

7. Centro Interdisciplinario de Neurociencia de Valparaíso

8. Facultad de Ciencias

Abstract

The emergence of different drug resistant strains of HIV-1 reverse transcriptase (HIV RT) remains of prime interest in relation to viral pathogenesis as well as drug development.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MB/C4MB00253A

Reference44 articles.

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4. Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine

5. Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: A review of the last 20 years (1989–2009)

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