In vitro selection of a peptide aptamer that potentiates inhibition of cyclin-dependent kinase 2 by purvalanol-Reference-Cited by-同舟云学术

In vitro selection of a peptide aptamer that potentiates inhibition of cyclin-dependent kinase 2 by purvalanol

Published:2014 Issue:9 Volume:5 Page:1400-1403
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Wang Wei¹²³,Hirano Yoshinori⁴⁵⁶⁷,Uzawa Takanori¹²³⁸⁹,Liu Mingzhe¹⁰¹¹¹²¹³,Taiji Makoto⁴⁵⁶⁷,Ito Yoshihiro¹²³⁸⁹

Affiliation:

1. Nano Medical Engineering Laboratory

2. RIKEN 2-1 Hirosawa

3. Wako, Japan

4. Laboratory for Computational Molecular Design

5. Computational Biology Research Core

6. RIKEN Quantitative Biology Center

7. Chuo-ku, Japan

8. Emergent Bioengineering Materials Research Team

9. RIKEN Center for Emergent Matter Science

10. Key Laboratory of Structure-Based Drugs Design & Discovery (Shenyang Pharmaceutical University) of Ministry of Education

11. School of Pharmaceutical Engineering

12. Shenyang Pharmaceutical University

13. , China

Abstract

To increase the inhibitory activity of purvalanol against cyclin-dependent kinase 2, we increased the extent of interaction between the inhibitor and the target by coupling a peptide aptamer to purvalanol.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C4MD00142G

Reference27 articles.

1. Protein Kinase Inhibitors: Insights into Drug Design from Structure

2. Targeting cancer with small molecule kinase inhibitors

3. Protein kinases — the major drug targets of the twenty-first century?

4. Features of Selective Kinase Inhibitors

5. The Protein Kinase Complement of the Human Genome

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