Synthesis of novel <i>C</i>-nucleoside analogues bearing an anomeric cyano and a 1,2,3-triazole nucleobase as potential antiviral agents-Reference-Cited by-同舟云学术

Synthesis of novel C-nucleoside analogues bearing an anomeric cyano and a 1,2,3-triazole nucleobase as potential antiviral agents

Published:2022 Issue:13 Volume:20 Page:2715-2728
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Sierocki Pierre¹^ORCID,Gaillard Krystal¹,Arellano Reyes Ruben Arturo¹^ORCID,Donnart Chloé¹,Lambert Emilie²,Grosse Sandrine³,Arzel Laurence¹,Tessier Arnaud¹^ORCID,Guillemont Jerome²,Mathé-Allainmat Monique¹^ORCID,Lebreton Jacques¹

Affiliation:

1. Nantes Université, CNRS, Laboratoire CEISAM–UMR 6230, Faculté des Sciences et des Techniques, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France

2. Janssen-Cilag, Campus de Maigremont BP615, F-27106 Val de Reuil, Cedex, France

3. Janssen Research & Development, Turnhotseweg 30, 2340 Beerse, Belgium

Abstract

We report the synthesis of C-nucleosides with a quaternary carbon at the anomeric position tethered to a 4-substituted 1,2,3-triazole ring and a cyano group, which were developed as potential antiviral agents.

Funder

Cilag

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D1OB02451E

Reference36 articles.

1. The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold

2. Intriguing Antiviral Modified Nucleosides: A Retrospective View into the Future Treatment of COVID-19

3. Design, synthesis, and broad spectrum antiviral activity of 1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides