Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation-Reference-Cited by-同舟云学术

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Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation

Published:2016 Issue:10 Volume:6 Page:8317-8328
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Wojtczak Blazej A.¹²³⁴,Warminski Marcin⁵⁶⁷²⁴,Kowalska Joanna⁵⁶⁷²⁴^ORCID,Lukaszewicz Maciej⁵⁶⁷²⁴,Honcharenko Malgorzata⁸⁹¹⁰,Smith C. I. Edvard¹¹⁹¹²¹⁰,Strömberg Roger⁸⁹¹⁰,Darzynkiewicz Edward¹²³⁴,Jemielity Jacek¹²³⁴^ORCID

Affiliation:

1. Centre of New Technologies

2. University of Warsaw

3. 02-089 Warsaw

4. Poland

5. Division of Biophysics

6. Institute of Experimental Physics

7. Faculty of Physics

8. Department of Biosciences and Nutrition

9. Karolinska Institutet

10. Sweden

11. Department of Laboratory Medicine

12. Karolinska University Hospital

Abstract

Phosphate-modified m₃G cap analogs were synthesized, conjugated to RNA using “click chemistry”, and studied for susceptibility to hNUDT16 enzyme.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA25684D

Reference39 articles.

1. The C. elegans Trans-spliced leader RNA is bound to Sm and has a trimethylguanosine cap

2. trans-spliced Caenorhabditis elegans mRNAs retain trimethylguanosine caps.

3. Specificity and Mechanism of RNA Cap Guanine-N2 Methyltransferase (Tgs1)

4. Hypermethylation of the Cap Structure of Both Yeast snRNAs and snoRNAs Requires a Conserved Methyltransferase that Is Localized to the Nucleolus

5. Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs

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1. Application of Mammalian Nudix Enzymes to Capped RNA Analysis;Pharmaceuticals;2024-09-11

2. Trimethylguanosine cap-fluorescent molecular rotor (TMG–FMR) conjugates are potent, specific snurportin1 ligands enabling visualization in living cells;Organic & Biomolecular Chemistry;2024

3. Insight into the Binding and Hydrolytic Preferences of hNudt16 Based on Nucleotide Diphosphate Substrates;International Journal of Molecular Sciences;2021-10-10

4. Combining Chemical Synthesis and Enzymatic Methylation to Access Short RNAs with Various 5′ Caps;ChemBioChem;2019-05-27

5. Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides;RNA;2018-02-26

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