Aromatic long chain cations of amphiphilic ionic liquids permeabilise the inner mitochondrial membrane and induce mitochondrial dysfunction at cytotoxic concentrations-Reference-Cited by-同舟云学术

Aromatic long chain cations of amphiphilic ionic liquids permeabilise the inner mitochondrial membrane and induce mitochondrial dysfunction at cytotoxic concentrations

Published:2023 Issue:15 Volume:25 Page:6067-6076
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Duman Meryem-Nur¹,Angeloski Alexander¹²^ORCID,Johnson Michael S.³⁴^ORCID,Rawling Tristan¹^ORCID

Affiliation:

1. School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, 2007, Australia

2. National Deuteration Facility, Australian Nuclear Science and Technology Organisation, Lucas Heights, Sydney, NSW, 2232, Australia

3. School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, 2007, Australia

4. School of Biomedical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, 2052, Australia

Abstract

Aromatic long chain cations of amphiphilic ionic liquids (AmILs) accumulate in and permeabilise the IMM at their cytotoxic concentrations. The AmILs depolarise IMM, inhibit oxidative phosphorylation and ATP synthesis, and induce ROS formation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/GC/D3GC00151B

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