AC2P20 selectively kills Mycobacterium tuberculosis at acidic pH by depleting free thiols-Reference-Cited by-同舟云学术

AC2P20 selectively kills Mycobacterium tuberculosis at acidic pH by depleting free thiols

Published:2021 Issue:33 Volume:11 Page:20089-20100
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Dechow Shelby J.¹²³⁴,Coulson Garry B.¹²³⁴,Wilson Michael W.⁵⁶⁷⁸⁴,Larsen Scott D.⁵⁶⁷⁸⁴,Abramovitch Robert B.¹²³⁴

Affiliation:

1. Department of Microbiology and Molecular Genetics

2. Michigan State University

3. East Lansing

4. USA

5. Vahlteich Medicinal Chemistry Core

6. College of Pharmacy

7. University of Michigan

8. Ann Arbor

Abstract

Mycobacterium tuberculosis (Mtb) is killed by the chemical probe AC2P20 at acidic pH, but not neutral pH. AC2P20 depletes Mtb free thiols at acidic pH showing Mtb is selectively sensitive to agents targeting thiol-redox homeostasis at acidic pH.

Funder

National Institute of Allergy and Infectious Diseases

AgBioResearch, Michigan State University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA03181C

Reference54 articles.

1. Latent Tuberculosis Infection: Myths, Models, and Molecular Mechanisms

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3. Acid Fasting: Modulation of Mycobacterium tuberculosis Metabolism at Acidic pH

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