Three-component [3 + 2] cycloaddition for regio- and diastereoselective synthesis of spirooxindole-pyrrolidines-Reference-Cited by-同舟云学术

Three-component [3 + 2] cycloaddition for regio- and diastereoselective synthesis of spirooxindole-pyrrolidines

Published:2022 Issue:8 Volume:46 Page:3866-3870
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Zhang Xiaofeng¹²^ORCID,Liu Miao¹,Zhan Desheng³,Kaur Manpreet⁴,Jasinski Jerry P.⁴^ORCID,Zhang Wei¹^ORCID

Affiliation:

1. Department of Chemistry and Centre for Green Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA

2. Department of Cancer Biology Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA

3. Department of Chemistry, Changchun Normal University, Changchun 130032, P. R. China

4. Department of Chemistry, Keene State College, Keene, NH 03435, USA

Abstract

Acid additive-promoted regio- and diastereoselective 1,3-dipolar cycloaddition of nonstabilized azomethine ylides with olefinic oxindoles afforded biologically interesting pirooxindole-pyrrolidines.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D1NJ05538K

Reference68 articles.

1. Therapeutic Potential of Spirooxindoles as Antiviral Agents

2. Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction

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