Synthesis of (−)-epibatidine
Author:
Affiliation:
1. Department of Chemistry
2. National Chung Hsing University
3. Taichung, Republic of China
Abstract
An asymmetric synthesis to the dendrobatid alkaloid (−)-epibatidine has been described, featuring chiral resolution of both optically pure 7-azabicyclo[2.2.1]heptanecarboxylic acid, and subsequent transformations to (−)-epibatidine.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA00770K
Reference29 articles.
1. Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an Ecuadoran poison frog
2. Alkaloids from frog skin: the discovery of epibatidine and the potential for developing novel non-opioid analgesics
3. Synthesis and nicotinic activity of epiboxidine: an isoxazole analogue of epibatidine
4. Chemistry of 7-Azabicyclo[2.2.1]hepta-2,5-dienes, 7-Azabicyclo[2.2.1]hept-2-enes, and 7-Azabicyclo[2.2.1]heptanes
Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Synthesis of dendrobatid alkaloid (+)-167B and (+)-209D and the investigation of diastereoselectivity using DFT calculations;RSC Advances;2017
2. ChemInform Abstract: Synthesis of (-)-Epibatidine.;ChemInform;2014-10-10
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