An isotope dilution mass spectrometry assay to track Norovirus-like particles in vaccine process intermediates by quantifying capsid protein VP1

Author:

Jhingree Jacquelyn R.1ORCID,Boisvert Julie1,Mercier Geneviève1

Affiliation:

1. Medicago Inc., 2552 Boulevard du Parc-Technologique, Québec, QC, G1P 4S6, Canada

Abstract

Development of a quantitative LC-MS/MS assay for tracking Virus-Like Particles (VLPs) in the purification of a candidate Norovirus vaccine drug substance produced in plants.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Reference31 articles.

1. C.Ruis , L.Thorne and J.Breuer , Norovirus , Springer , Switzerland , 2019

2. Global Burden of Norovirus and Prospects for Vaccine Development , https://web.archive.org/web/20180711021911/https://www.cdc.gov/norovirus/downloads/global-burden-report.pdf , accessed March 2023

3. Our Vaccine Candidates , https://medicago.com/en/our-science/our-vaccine-candidates , accessed March 2023

4. Norovirus protein structure and function

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